Evidence Shows Curcumin Boosts Mood

Curcumin is a bioactive compound found in turmeric, a spice commonly used in Indian cuisine. It has been studied extensively for its anti-inflammatory and antioxidant properties, as well as its potential to improve mood and cognitive function. In this blog, we will explore the research on the benefits of curcumin for low mood and depression, including the scientific references supporting these claims.

1. Curcumin Reduces Inflammation

Inflammation is believed to play a role in the development of depression, and many antidepressant medications work by reducing inflammation in the brain. Curcumin has been shown to have potent anti-inflammatory effects, which may help to alleviate symptoms of depression. A 2017 meta-analysis of 10 randomized controlled trials found that curcumin significantly reduced levels of the inflammatory marker C-reactive protein (CRP) in people with depression (1).

2. Curcumin Improves Neurotransmitter Function

Neurotransmitters are chemicals in the brain that are involved in mood regulation. Low levels of certain neurotransmitters, such as serotonin and dopamine, have been linked to depression. Curcumin has been shown to increase the levels of these neurotransmitters in the brain, potentially improving mood and reducing symptoms of depression. A 2018 study found that curcumin supplementation increased levels of both serotonin and dopamine in mice (2).

3. Curcumin Boosts Brain-Derived Neurotrophic Factor (BDNF)

BDNF is a protein that plays a key role in the growth and maintenance of brain cells. Low levels of BDNF have been linked to depression and other mood disorders. Curcumin has been shown to increase BDNF levels in the brain, potentially improving cognitive function and reducing symptoms of depression. A 2017 study found that curcumin supplementation increased BDNF levels in healthy young adults (3).

4. Curcumin May Enhance the Effects of Antidepressant Medications

Some studies suggest that curcumin may enhance the effects of antidepressant medications, potentially allowing for lower doses of medication to be used. A 2019 randomized controlled trial found that curcumin supplementation improved symptoms of depression in people taking an antidepressant medication (4).

5. Curcumin is Safe and Well-Tolerated

Curcumin is generally considered safe and well-tolerated, with few side effects reported in clinical studies. However, high doses of curcumin may cause gastrointestinal side effects such as nausea and diarrhea. It is important to speak with a healthcare provider before starting any new supplement regimen.

In conclusion, curcumin has shown promising results for its potential to improve low mood and depression. Its anti-inflammatory effects, ability to improve neurotransmitter function, boost BDNF levels, and potential to enhance the effects of antidepressant medications make it a promising natural treatment option. However, more research is needed to fully understand the mechanisms of action and optimal dosing regimens for curcumin supplementation.


1. Ng QX, Koh SSH, Chan HW, Ho CYX. Clinical use of curcumin in depression: A meta-analysis. J Am Med Dir Assoc. 2017;18(6):503-508. doi:10.1016/j.jamda.2016.12.071

2. Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. 2011;12(3):332-347. doi:10.2174/138945011794815356

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